Answer posted - Why was this high school student losing weig
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Suraj Jethlani
Answer posted - Why was this high school student losing weight and feeling so sick?
Option 4 is the correct answer. Cate had a rare disorder known as tubulointerstitial nephritis and uveitis syndrome, also known as TINU which typically affects adolescent girls and may be the result of an autoimmune malfunction. In some cases, it is preceded by an infection. Cate’s mycoplasma infection might have triggered it, although there is no way to know for certain. The hallmark symptoms of TINU are uveitis and interstitial nephritis. Other symptoms of TINU include weight loss and weakness. Treatment typically involves steroids. To date, only 200 cases have been reported in the medical literature worldwide, and many doctors are unaware of its existence. Cate had started using steroid eye drops that her ophthalmologist had prescribed at the first visit; within a few weeks, she felt better and gained weight more rapidly. She began receiving injections of methotrexate, a drug used to treat certain cancers because steroids alone have not cleared the uveitis. Her kidneys are again functioning normally.

Case Facts
Cate Chapin’s January illness bore the hallmarks of the flu: Lethargic, achy and feverish. The paediatrician decided she probably had pneumonia and prescribed antibiotics to knock out the lung infection. The antibiotics didn’t help, and two days later, Davidge took Cate to a nearby emergency room. While undergoing a chest X-ray to confirm the pneumonia diagnosis, Cate fainted. The probable cause was dehydration; doctors gave her an IV drip to rehydrate her and anti-nausea medications. The chest X-ray had found nothing. Nor did subsequent blood tests reveal a reason for Cate’s worsening weakness and dramatic weight loss. She underwent an endoscopy and colonoscopy and an extensive GI workup, which uncovered nothing. 3 weeks after she was discharged, Cate was resting at home when she suddenly developed an intense sharp pain in her left eye, which was also badly inflamed.

Option 1: Cancer

Option 2: Fanconi syndrome

Option 3: Juvenile rheumatoid arthritis

Option 4: Tubulointerstitial nephritis and Uveitis syndrome

https://www.washingtonpost.com/national/health-science/why-was-this-high-school-student-losing-weight-and-feeling-so-sick/2013/11/18/fc94fcb2-2eba-11e3-8906-3daa2bcde110_story.html?utm_term=.61916a31f960
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