Anti-inflammatory Medication After Cataract Surgery and Post
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Cataract surgery is one of the most common surgeries in the world and the most common procedure performed. Topical anti-inflammatory drops (steroids and nonsteroidal anti-inflammatory drugs [NSAIDs]) are typically used for 1-3 months following the operation. They suppress the inflammatory reaction and reduce postoperative pain, discomfort, and complications such as pseudophakic cystoid macular edema. Posterior capsular opacification (PCO) remains among the most common complications after cataract surgery. It may cause reduced vision and it is estimated to occur in approximately 5%-10% of cases.

A total of 13,368 patients were included in the analysis, 61.7% were female. Pseudoexfoliation was noted in 10.1% of cases. The mean follow-up time was 22.8 months. Patients were treated with steroid monotherapy (28.9% of cases), NSAID monotherapy (62.2%), or a combination of both (8.9%). Treatment with steroids resulted in significantly lower Nd:YAG capsulotomy rates compared to NSAIDs. Treatment with combination therapy of steroids and NSAIDs showed no added benefit over steroid monotherapy. Cox regression analysis adjusted for patients' age, sex, pseudoexfoliation, and risk stratification remained significantly predictive for lower capsulotomy rates with steroid treatment over NSAIDs.

Postoperative treatment with steroids among patients undergoing uncomplicated cataract surgery was associated with lower rates of clinically significant posterior capsule opacification compared to treatment with NSAIDs alone. Combination therapy of steroids and NSAIDs had no added benefit over steroids alone.

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