Antibodies against citrullinated proteins in relation to per
Previous studies have reported conflicting findings between serum anti-citrullinated protein antibodies (ACPA) levels in rheumatoid arthritis (RA) participants with and without periodontitis (Pd). This study suggests higher levels of ACPA are present in RAPd.

This study aimed to analyze possible correlations between serum ACPA levels and clinical parameters in Pd and RA participants.

Full mouth periodontal examination (probing pocket depth, clinical attachment levels, gingival bleeding index, visual plaque index) was conducted and serum samples were obtained from 80 participants comprising RA, Pd, both RA, and Pd (RAPd), and healthy individuals (HC). Erythrocyte sedimentation rates (ESR) and periodontal inflamed surface area (PISA) were obtained. Serum samples were analyzed for ACPA quantification using ELISA.

- Median levels of ACPA in RAPd, RA, Pd, and HC groups were 118.58, 102.02, 78.48, and 51.67 respectively.

- ACPA levels were significantly higher in RAPd and RA as compared to the HC group.

- However, ACPA levels of any of the groups were not correlated with any clinical periodontal and RA parameters within the respective groups.

In summary, at the individual level, the amount of serum ACPA seems to have an increasing trend with the diseased condition in the order of RAPd?>?RA?>?Pd?>?HC.

BMC Oral Health
Source: https://doi.org/10.1186/s12903-021-01712-y
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