Antibody Cocktail Prevented Covid When Given As Simple Injec
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Regeneron Pharmaceuticals said that a single administration of its monoclonal antibody cocktail reduced the risk that volunteers exposed to Covid-19 would develop the disease by 81%. The study enrolled 1,500 healthy volunteers, each of whom shared a home with someone who tested positive for SARS-CoV-2, and randomized them to receive a single dose of its antibody treatment, given subcutaneously as four shots, or placebo.

After 29 days, 11 patients in the treatment group developed Covid-19 compared to 59 on placebo. And for the subjects who got Covid-19 despite treatment, their symptoms resolved after one week, compared to three weeks for those on placebo. In 204 patients who had already tested positive for the SARS-CoV-2 virus at the study’s outset, the injection reduced their chances of progressing to symptomatic Covid-19 by 31%.

“In order for these antibodies to be used for treatment and prevention and for treatment as prevention, we need the patients or their families familiar with the opportunity,” a researcher said. “We need health providers to be familiar with these drugs and comfortable administering them.”

And why do we need antibodies when there are already vaccines?

Dan Barouch, the director of the Center for Virology and Vaccine Research at Beth Israel Deaconess Medical Center and a key figure in the development of the J&J vaccine and another investigator in Regeneron’s study said that the approaches are complementary. As of now, there are still substantial numbers of people who are not fully vaccinated. What’s more, some people, including those with compromised immune systems, might not generate enough antibodies on their own and could benefit from antibodies that are injected into their bodies.

In some circumstances, say, an outbreak at a nursing home, the monoclonal antibodies, which start working immediately, could be the better approach. Adverse events occurred in 20% of those who received the antibody cocktail and 29% of those who received a placebo. None of the antibody cocktail recipients were hospitalized, but four volunteers in the placebo group were. Injection site reactions occurred in 4% of those who received the antibody and 2% of those who received placebo.

Source:
https://www.statnews.com/2021/04/12/regeneron-antibody-cocktail-covid-simple-injection/?utm_campaign=rss
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Why a single dose is given as four shots ?
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