Antidepressants Provide No Important Benefits For Managing L
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A new systematic review found that treating low back pain with antidepressant medicines provides no important benefits and has the potential to cause harm. The most commonly used treatments for low back pain are medicines that aim to reduce this pain. Often, antidepressants are prescribed to people with low back pain when other medicines fail to provide relief.

The new study consolidated the results of 17 studies involving more than 2500 adult participants. The researchers compared the results of five different antidepressant medicine classes to the use of placebos. They investigated the differences in outcomes for pain, safety, function, and depressive symptoms between people taking antidepressants and placebos.

The results of the study challenge six international guidelines that recommend the use of antidepressant medicines for chronic low back pain. In particular, the United States’ clinical guideline endorses duloxetine, serotonin, and norepinephrine reuptake inhibitor, for the treatment of chronic low back pain.

The researchers, however, found no important pain-relieving effects from the use of duloxetine or, any other class or dose of antidepressant medicines. Ongoing recommendations for the use of antidepressants to treat low back pain are concerning, particularly given the increased risk of side effects.

Source:
https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-021-01599-4
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