Antifungal And Antidepressant Drugs May Help Protect Against
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New research indicates that two currently available medications—an antifungal drug and an antidepressant—can effectively inhibit the virus that causes COVID-19 in laboratory cells. Investigators found that the antifungal itraconazole and the antidepressant fluoxetine each blocked the production of infectious SARS-CoV-2 virus in cell culture lab tests.

Researchers tested the antiviral potential of the antifungal itraconazole and the antidepressant fluoxetine on the production of infectious SARS-CoV-2 particles in the polarized Calu3 cell culture model and evaluated the added benefit of a combinatory use of these host-directed drugs with the direct-acting antiviral remdesivir, an inhibitor of viral RNA polymerase.

Drug treatments were well tolerated and potently impaired viral replication. Importantly, both itraconazole–remdesivir and fluoxetine–remdesivir combinations inhibited the production of infectious SARS-CoV-2 particles more than 90% and displayed synergistic effects, as determined in commonly used reference models for drug interaction.

"Preventive vaccination and therapeutic medicines against COVID-19 are both required to effectively combat pandemics caused by emerging zoonotic viruses such as SARS-CoV-2," said senior author Ursula Rescher, Ph.D., of the University of Muenster, in Germany.

Source:
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15418
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