Aprismatic enamel-like layer on a demineralized enamel using
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
According to this newer research, steady delivery of amorphous calcium phosphate (ACP) through carboxymethyl chitosan (CMC) and lysozyme nanogels helps forming enamel like layer.

The purpose of this study was to prepare carboxymethyl chitosan (CMC) and lysozyme nanogels that could encapsulate amorphous calcium phosphate (ACP) for achieving its controlled delivery, thus forming an aprismatic enamel-like layer on the demineralized enamel surface.

CMC/LYZ-ACP nanogels were developed, and the controlled delivery of ACP from the nanogels was induced by the presence of NaCl. The nanogel morphologies at various NaCl concentrations was measured by transmission electron microscopy (TEM). The particle sizes and zeta potentials of the samples were determined using a combined dynamic light scattering/particle electrophoresis instrument. Comparing the remineralization effect of the CMC/LYZ-ACP nanogels on the demineralized enamel surface with that of a fluoride treatment, the remineralization effect was examined.

--CMC/LYZ-ACP nanogels were negatively charged spherical structures with a particle size of approximately 300 nm.

--At high concentrations of NaCl, ACP was dissociated from the disassembled nanogels and transformed into hydroxyapatite (HAP).

--Groups treated with the CMC/LYZ-ACP nanogels showed the regeneration of an aprismatic enamel-like layer on an acid-etched enamel surface, which provided increased mechanical properties and a high impermeability compared to those of the fluoride-treated group.

Conclusively, the stable and controllable delivery of ACP from CMC/LYZ-ACP nanogels, which can form an aprismatic enamel-like layer in situ on the surface of demineralized enamel.

Journal of Dentistry
Source: https://doi.org/10.1016/j.jdent.2021.103599
Like
Comment
Share