Arm-mounted OCTA in extremely low birth weight neonates with
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Preterm birth results in foveal changes as well. The foveal avascular zone (FAZ) in full-term infants normally develops by centrifugal migration of inner retinal layers. Preterm neonates are known to have retained inner retinal layers when imaged with handheld optical coherence tomography (OCT). A study was done to assess the feasibility of imaging extremely low birth weight infants, defined as infants born weighing less than 1000 g or before 27 weeks of gestational age, with an arm-mounted optical coherence tomography angiography (OCTA) device.

Seven ELBW infants were included with an average gestational age of 25 weeks and average postmenstrual age of 54.7 weeks at the time of imaging. Average birth weight was 615 g. Thirteen eyes had ROP treatment including primary laser, anti-vascular endothelial growth factor injection with delayed laser, and scleral buckle. Six infants were imaged under general anesthesia and one infant was imaged without sedation. Average FAZ area was 0.17 mm2 in the SCP and 0.04 mm2 in the DCP. FAZ area correlated positively to the ratio of outer retinal layer thickness to inner retinal layer thickness at the foveal center in the SCP and DCP and negatively with an inner retinal layer thickness in the SCP.

The current study establishes the feasibility of using an arm-mounted OCTA device to image ELBW neonates and increases our knowledge of foveal development. Future studies can also address the question of if and how laser and anti-VEGF treatment for peripheral ROP affects foveal maturation by imaging before and after treatment.