Arthritis drug Baricitinib shows promise against COVID-19, s
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
A drug against rheumatoid arthritis called baricitinib could potentially be repurposed to treat patients with COVID-19, according to a study conducted by an international research team including researchers at Karolinska Institutet in Sweden. The findings, published in the journal EMBO Molecular Medicine, represent an example of how artificial intelligence (AI)-algorithms could help identify existing drugs as potential therapies against as new illnesses.

Baricitinib is a once-daily oral drug used for treatment of adult patients with moderate to severe rheumatoid arthritis. It acts as an inhibitor of janus kinase, a type of enzyme that acts as an "on" or "off" switch in many cellular functions. The drug works by interfering with the inflammatory processes of the immune system and has been viewed as a potential treatment candidate for COVID-19.

Lab tests and clinical pilot study

In test tubes and 3-D-human miniature livers, the researchers showed that the drug inhibited signaling of cytokines, immune system-proteins known to overreact and drive inflammation in severe cases of COVID-19 infection. It also helped reduce the viral load of SARS-CoV-2, the virus that causes COVID-19, and the level of the signal molecule interleukin-6 (IL-6), a predictor of mortality from acute respiratory distress syndrome associated with COVID-19.

In addition to the lab tests, a small pilot study of three men and one woman with bilateral COVID-19 pneumonia was conducted in Milan, Italy. After 10-12 days of treatment with baricitinib, all four patients showed improvements in signs and symptoms such as cough, fever and reductions in viral load and plasma IL-6 levels.

Additional trials of baricitinib are currently underway in 85 hospitalized COVID-19 patients across three hospitals in Northern and Central Italy, with encouraging initial results in patient outcomes, according to the researchers.

Source: https://www.embopress.org/doi/abs/10.15252/emmm.202012697
Dr. S●●●●●m S●●●●y P●●●●●l and 5 others like this7 shares
Like
Comment
Share
Dr. S●●●●●m S●●●●y P●●●●●l
Dr. S●●●●●m S●●●●y P●●●●●l General Medicine
Interesting read. We are looking forward to Phase 2 and 3 results too.
Jun 14, 2020Like1