Aspirin associated with a decreased incidence of uterine can
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Aspirin exerts an anti-tumor effect via the COX pathway. Clinical studies on the chemopreventive effects of Aspirin on uterine cancer (UC) remain inconsistent. Researchers used a population-based retrospective cohort study to evaluate uterine cancer in Aspirin users in Taiwanese women. Researchers identified 23,342 women who received Aspirin treatment between 2000 and 2010 and a comparison group of the same sample size randomly selected from the same database matched by the propensity score. The incidence of uterine cancer in the Aspirin cohort was 10% of that in the comparison group (0.28 vs 2.73 per 10,000 person-years). The Poisson regression analysis estimated adjusted incidence rate ratio (IRR) was 0.10 (95%) for Aspirin users relatives to comparisons after controlling for covariates. The uterine cancer incidence in Aspirin users decreased with age, from 0.61 per 10,000 person-years in the 20 to 39 years old. The incidence was higher in long term users. Hormone therapy of estradiol was associated with the increase of uterine cancer risk in both cohorts, but less in Aspirin users than comparisons (1.34 vs 4.75 per 10,000 person-years). This study suggests that Aspirin use was associated with a decreased risk of uterine cancer.

In conclusion, findings suggest that Aspirin use was associated with a decreased risk of uterine cancer. This association remains significant for shorter-term users. These findings add to the literature implicating that the anti-cancer effect of Aspirin is particularly notable for uterine cancer. Further prospective randomized clinical trials are warranted to confirm these findings.

Source: https://journals.lww.com/md-journal/subjects/Obstetrics and Gynecology/Fulltext/2020/07310/Aspirin_associated_with_a_decreased_incidence_of.92.aspx
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