Assessment of Retinal Thinning in Adults With and Without Si
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A Study was conducted to assess the rates of macular thinning in adults with and without sickle cell retinopathy using spectral-domain optical coherence tomography (OCT) and to identify ocular and systemic risk factors associated with retinal thinning.

Participants with sickle cell retinopathy (sickle cell group) were matched by age and race with participants without sickle cell retinopathy (control group). They received annual spectral-domain OCT and clinical examinations.

Results:
--Among 370 adults enrolled in the study, 310 participants had sickle cell retinopathy, and 60 participants did not.

--Of those, 175 of 310 participants in the sickle cell group and 31 of 60 participants in the control group had at least 1 year of clinical and spectral-domain OCT follow-up data from baseline. The mean (SD) follow-up was 53.7 (32.6) months for the sickle cell group and 54.6 (34.9) months for the control group.

--Rates of macular thinning in the sickle cell group were significantly higher than those in the control group for the inner nasal (difference, ?1.18 microm per year), inner superior (difference, ?1.03 ?m per year), inner temporal (difference, ?0.61 ?m per year), and outer nasal (difference, ?0.41 ?m per year) quadrants.

--Patients with sickle cell hemoglobin SC and sickle cell hemoglobin beta-thalassemia subtypes had higher rates of retinal thinning than those with the sickle cell hemoglobin SS subtype.

--Risk factors associated with greater rates of retinal thinning included participant age, stage of retinopathy, previous stroke, and presence of hypertension, acute chest syndrome, or diabetes.

--Hydroxyurea therapy was associated with decreased rates of retinal thinning and may be a protective factor.

In this study, participants with sickle cell retinopathy had higher rates of retinal thinning than those without sickle cell retinopathy, that increased with participant age and stage of retinopathy. These results imply that detecting anatomic worsening of sickle cell maculopathy using spectral-domain OCT can be a useful parameter for monitoring the progression of sickle cell retinopathy.

Source: https://jamanetwork.com/journals/jamaophthalmology/fullarticle/2775807
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