Assessment of diffusion tensor imaging in differentiation be
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Pyogenic spondylitis had a higher mean diffusivity than tuberculous spondylitis. Pyogenic spondylitis had lower fractional anisotropy than tuberculous spondylitis. DTI parameters help in differentiation pyogenic from tuberculous spondylitis.

The purpose of this study was to assess diffusion tensor imaging (DTI); an emerging technique for differentiation between pyogenic and tuberculous spondylitis.

The study was carried out on 33 patients with infective spondylitis performing conventional MRI and DTI. The mean diffusivity (MD) and fractional anisotropy (FA) of the affected vertebral body were calculated by two readers.

--The MD of pyogenic spondylitis of both readers were significantly higher values than tuberculous spondylitis. The FA of pyogenic spondylitis of both readers were significantly lower values than tuberculous spondylitis.

--There was a strong inter-reader agreement between both readers using MD and FA.

--The thresholds MD and FA used for differentiating pyogenic and tuberculous spondylitis of both readers were 1.37 and 1.33?×?10?3?mm2/s and 0.21 and 0.25 with the area under the curve (AUC) of 0.927 and 0.831 respectively.

--Combined MD and FA revealed increased AUC to 0.97 and 0.98 of both readers respectively.

In particular, DTI with its parameters can be considered a noninvasive beneficial quantitative method that can help in the differentiation between pyogenic and tuberculous spondylitis.

European Journal of Radiology
Source: https://doi.org/10.1016/j.ejrad.2021.109695
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