Association Between Alopecia Areata and Natural Hair Color A
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Alopecia areata (AA) is a complex immune-mediated disorder that causes nonscarring hair loss. A Study was conducted to investigate the association of alopecia areata with hair color among White residents of the UK.

This matched, case-control study used a large prospectively acquired cohort and included data that were collected from the UK Biobank, a large-scale prospective resource designed to study phenotypic and genotypic determinants in adults. A total of 502510 UK Biobank participants were reviewed for inclusion. Among these individuals, 1673 cases of alopecia areata with reported hair color were captured and matched by age and sex to 6692 controls without alopecia areata using 1:4 matching.

Conditional logistic regression analysis was performed, in which the outcome variable was alopecia areata and the main predictor was natural hair color before graying. The variables considered included diabetes, hypothyroidism, hyperthyroidism, and vitiligo.

--Of 464353 participants, 254505 were women, and the mean (SD) age for those with alopecia areata was 46.9 years.

--Alopecia areata was significantly more common in individuals with black (adjusted odds ratio [aOR], 2.97) and dark brown hair (aOR, 1.26) compared with light brown hair.

--In contrast, blond individuals exhibited significantly decreased alopecia areata compared with those with light brown hair (aOR, 0.69).

--Red hair color was not significantly different from light brown hair.

The findings of this matched case-control study seem to indicate that alopecia areata is modulated by natural hair color, preferentially targeting darker hair. The results support a previously proposed model of alopecia areata in which immunity is directed against melanogenesis-associated proteins in the anagen hair follicles.