Association Between Fexofenadine Use During Pregnancy and Fe
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Fexofenadine hydrochloride is a frequently used drug for treatment of allergic conditions during pregnancy, but the fetal safety of fexofenadine use has not been well studied.

This study aimed to investigate the risk of adverse fetal outcomes associated with fexofenadine use during pregnancy. A nationwide registry-based cohort study was conducted on pregnancies in Denmark and data analysis was performed. From a cohort of 1?287?668 pregnancies, fexofenadine use was compared with cetirizine hydrochloride use during pregnancy, matched in a 1:1 ratio on propensity scores.

Results: For the analyses of major birth defects and spontaneous abortion, a total of 2962 and 4901 pregnancies with fexofenadine use were included, respectively, matched in a 1:1 ratio with pregnancies with cetirizine use.
-- Infants born with major birth defects occurred in 118 pregnancies with fexofenadine use compared with 112 pregnancies with cetirizine use.
-- Spontaneous abortion occurred in 413 pregnancies with fexofenadine use compared with 439 pregnancies with cetirizine use.
-- Fexofenadine use during pregnancy was not associated with an increased risk of major birth defects or spontaneous abortion compared with cetirizine use during pregnancy.
-- Preterm birth occurred in 370 pregnancies with fexofenadine use compared with 382 pregnancies with cetirizine use, SGA occurred in 515 pregnancies with fexofenadine use compared with 523 pregnancies with cetirizine use, and a total of 16 pregnancies with fexofenadine use ended in stillbirth compared with 24 pregnancies with cetirizine use.

Conclusively, Use of fexofenadine during pregnancy does not appear to be associated with an increased risk of adverse fetal outcomes.

Source: https://jamanetwork.com/journals/jamapediatrics/article-abstract/2766302
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