Association betweeen Fatty Acids and Osteoarthritis, finds S
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Inflammation worsens joint destruction in osteoarthritis (OA) and aggravates pain. Saturated and n-6 fatty acids (FAs) increase, whereas n-3 FAs reduce inflammation. A Study was conducted to examine whether FA levels affected the development of OA.

Researchers studied participants from the Multicenter Osteoarthritis study (MOST) at risk of developing knee OA. After baseline, repeated knee x-rays and MRIs were obtained and knee symptoms were queried through 60 month follow-up. Using baseline fasting samples, serum FAs were analyzed with standard assays. After excluding participants with baseline OA, two sets of cases were defined : those developing radiographic OA and those developing symptomatic OA (knee pain and radiographic OA).

Controls did not develop these outcomes. Additionally, worsening of MRI cartilage loss and synovitis and of knee pain was also examined using WOMAC and the number of hand joints affected by nodules were evaluated . In regression models, the association of each OA outcome with levels of saturated, n-3 and n-6 FAs adjusting for age, sex, BMI, education, race, baseline pain and depressive symptoms were tested.

Results
--260 cases with incident symptomatic and 259 with incident radiographic OA were studied. Mean age was 61 years (61% women).

--No signficant nor suggestive associations of FA levels with incident OA (e.g. for incident symptomatic OA, OR per s.d. increase in n-3 FA 1.00 (0.85, 1.18) nor with any OA outcome in knee or hand were found.

In conclusion, despite previously reported effects on systemic inflammation, FA levels in the blood were not associated with the risk of later knee OA or other OA outcomes.

Source: https://www.sciencedirect.com/science/article/abs/pii/S1063458421006373?dgcid=rss_sd_all
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