Association between CS and QOL in Central Retinal Vein Occlu
A Study was conducted to investigate the relationship between contrast sensitivity (CS) and vision-related quality of life (VR-QOL) in patients with central retinal vein occlusion following ranibizumab intravitreal injection; CS showed a stronger association with VR-QOL than visual acuity.

Researchers investigated the relationship between CS, VR-QOL and optical coherence tomography (OCT) findings in patients with cystoid macular oedema secondary to central retinal vein occlusion (CRVO-CMO) following intravitreal injection of ranibizumab.

The study included 23 patients with CRVO-CMO who were followed up for 12 months after treatment. The best-corrected visual acuity (BCVA), letter contrast sensitivity (LCS) and OCT images were obtained every month.

Results:
--The LCS and VFQ-25 composite score improved significantly from baseline to 12 months following treatment.

--The multiple regression analysis revealed that the LCS of the affected eye and BCVA of the fellow eye were related to the VFQ-25 composite score following treatment.

--The LCS improvement showed a significant correlation with the improvement in the VFQ-25 composite score, whereas the BCVA improvement was not correlated with the improvement in the VFQ-25 composite score.

--Stepwise multiple regression analyses revealed that, at the time of macular oedema resolution, the distance between the external limiting membrane and retinal pigment epithelium (ELM-RPE) and average ganglion cell-inner plexiform layer (GCIPL) thickness were associated with LCS.

Conclusively, in patients with CRVO-CMO, CS exhibited a stronger relationship with VR-QOL than BCVA. CS was linked to ELM-RPE thickness and average GCIPL thickness after macular oedema was resolved.

Source: https://bjo.bmj.com/content/early/2021/08/26/bjophthalmol-2021-319863?rss=1
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