Association between Inflammation and endothelial dysfunction
A Study was conducted to evaluate the association between migraine and serum biomarkers of inflammation and endothelial dysfunction in children. Inflammation and endothelial dysfunction are the suggested underlying mechanisms in migraine. Pentraxins, C-reactive protein, erythrocyte sedimentation rate, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio are good indicators of inflammation. Alterations in insulin levels and insulin sensitivity may trigger endothelial dysfunction.

Children with migraine and healthy subjects were recruited. Serum samples were obtained in an attack-free period. Researchers compared these to clinical data such as age, sex, disease duration, attack frequency, attack duration, analgesic use, family history, and Pediatric Migraine Disability Assessment Questionnaire scores.

Results:
--Researchers assessed samples from 32 children with migraine and 19 healthy control.

--It was found significantly higher pentraxin-3, insulin, and insulin resistance in patients with migraine.

--A positive directional correlation is found between pentraxin-3 and Pediatric Migraine Disability Assessment Questionnaire scores.

--The best cut-off values for pentraxin-3 is determined between 12.75 pg/mL to 15 pg/mL in migraineurs.

Conclusively, Increased pentraxin-3 levels lend credence to the notion that inflammation plays a role in pediatric migraine. A spike in insulin and insulin resistance levels indicates vascular endothelial dysfunction. These findings lend credence to the notion that continuous inflammation and vascular endothelial dysfunction may play a role in migraine development in children.

Source: https://onlinelibrary.wiley.com/doi/10.1111/ped.14946?af=R
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