Association between Pregnancy and inflammatory bowel disease
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The prevalence of inflammatory bowel disease (IBD) has risen rapidly. The peak incidence of IBD is in the second to fourth decades, which coincides with the peak years of fertility and pregnancy. Because IBD is an immune‐mediated chronic inflammatory intestinal condition, the therapeutic aim is not a complete cure but to induce and maintain remission. Vague anxiety that IBD is an intractable disease can drive patients into avoiding pregnancy or to stop IBD medication arbitrarily. Therefore, it is an important obligation and the responsibility of clinicians who manage women with IBD to establish the impact of IBD on pregnancy and infant outcomes.

The study was done to determine the incidence rates of pregnancy outcomes in women with IBD. In addition, it sought to compare the risk according to disease severity.

The pregnancy rate of women with IBD was lower than that of women without. Cesarean section and intrauterine growth retardation were increased in CD patients than the controls. In regards to disease severity, there were no significant differences in pregnancy outcomes between patients with quiescent to mild IBD and the controls. However, the live birth rate of patients with moderate to severe IBD was lower than that of the controls. In addition, moderate to severe IBD was significantly associated with spontaneous abortion, cesarean section.

In conclusion, women with IBD have a lower pregnancy rate compared to non‐IBD women. Women with CD or moderate to severe disease have a higher rate of receiving cesarean section. Although the risks of adverse pregnancy outcomes are increased in patients with moderate to severe disease, women with quiescent to mild disease have similar pregnancy outcomes compared to those of non‐IBD controls. Therefore, we suggest that women with IBD who are preparing for pregnancy should be treated more intensively by physicians to reach a remission stage in the disease.

Source: https://onlinelibrary.wiley.com/doi/full/10.1111/apt.15654
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