Association between Statin use and the Reoperation rates in
A Study was conducted to examine the association of systemic statin therapy and reoperation rate after glaucoma filtration surgery (GFS).

This is a population-based, historic cohort study of 2705 eyes undergoing GFS in Finland. Baseline sociodemographic and health characteristics were documented. Reoperation rates of GFS subgroups were analysed, with statin users compared to non-users. The outcomes were modelled using a Poisson regression model adjusted for age, sex, education, statin use, chronic comorbidities, and cataract surgery with incident rate ratios (IRR) as the main outcome measure.

--The cohort contained 2263 subjects with open-angle glaucoma (OAG), 823 men and 1440 women. Surgery was performed on 2705 eyes.

--First documented procedures were deep sclerectomy (DS) (n = 1601), trabeculectomy (TRE) (799) and glaucoma drainage device (GDD) implantation (305) respectively.

--In total, 438 secondary operations were performed during the 7.5?year follow-up period. The reoperation rates were 19% after DS, 12% after TRE, and 13% after GDD.

--Of the surgical procedures, 32% were performed on eyes of patients receiving statin therapy.

--Statin users showed no difference in reoperation rates (IRR 1.06). In subgroups, no difference was observed in the reoperation rates adjusted with statin use after filtration surgery (DS, TRE) (IRR 1.06) or GDD implantation (0.57).

Conclusively, Systemic statin therapy had no effect on secondary surgery rates after DS, TRE, or GDD implantation in surgically treated OAG patients.