Association between overweight/obesity and vertebral fractur
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To determine the association between obesity/overweight and vertebral fractures in older adults, a meta-analysis of observational studies was performed. Overweight was found to be associated with a decreased risk of vertebral fractures in the female and non-Asian populations, whereas obesity, based on current evidence, was not associated with vertebral fracture risks.

Recent investigations suggest that the influence of overweight/obesity on fracture risks is site-specific, while conflicting data were reported related to vertebral fracture. This meta-analysis was performed to qualitatively assess the relationship between overweight/obesity and the risk of vertebral fracture.

MEDLINE, Web of Science, Embase, and Cochrane were searched for relevant observational articles assessing the vertebral fracture risk of the overweight or obese population compared to normal population. Two independent reviewers conducted data extraction and quality assessment.

Results:
11 studies including 1,078,094 participants were extracted from 1645 records.
-Pooled RR showed that decreased risk of vertebral fractures was observed in the overweight older adults (RR: 1.16), but not in the obese populations (RR: 0.98).
-In the subgroup analysis, we found a significant inverse association between overweight and risk of vertebral fracture in women (RR: 0.92), non-Asian areas (RR: 0.89), sample size more than 2000 (RR: 0.87), and quality score more than 7 (RR: 0.87). Furthermore, pooled studies of sample size more than 2000 (RR: 0.66) and quality score more than 7 (RR: 0.75) showed that the people with obesity had a significantly lower prevalence of vertebral fracture.

In particular, overweight aged adults tend to have a lower vertebral fracture risk. When gender and ethnicity were taken into consideration, the inverse relationship between overweight and vertebral fracture risk were only observed in female and non-Asian populations.

Source: https://link.springer.com/article/10.1007/s00198-020-05764-8
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