Association between prediabetes and adverse outcomes in hear
Heart failure (HF) patients with diabetes experienced significantly worse outcomes than those without diabetes. However, data on the prognostic impact of prediabetes in HF are inconclusive. This meta-analysis aimed to explore the association between prediabetes and the risk of all-cause mortality and adverse cardiac outcomes in HF patients.

Researchers searched multiple electronic databases for relevant studies. Studies were included for analysis if multivariable adjusted relative risks of adverse outcomes were reported in prediabetic HF patients compared with those with normoglycaemia.

-- Twelve studies comprising 28 643 HF patients reported the risk of all-cause mortality and cardiac outcomes associated with prediabetes were included.

-- The prevalence of prediabetes ranged from 9.6% to 37.2%. After a median follow-up duration of 2.3 years, HF patients with prediabetes were associated with an increased risk of all-cause mortality, cardiovascular mortality, HF hospitalization, all-cause mortality and/or HF hospitalization, as well as cardiovascular mortality and/or HF hospitalization, respectively.

Conclusively, Prediabetes is associated with a worse prognosis in patients with HF. Further risk stratification and effective treatment strategies are needed in prediabetic HF patients to improve the prognosis.