Association between quality of life and patient-reported com
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Remnant radioiodine ablation is discouraged in low-risk differentiated thyroid cancer because it confers no survival advantage. This study suggests that remnant radioiodine ablation is associated with lower health-related quality of life in early-stage differentiated thyroid cancer survivors.

A retrospective matched-pair analysis was conducted in stage I differentiated thyroid cancer survivors recruited from a thyroid cancer support group. Respondents self-reported via online survey. Dysphonia and dysphagia were reported via Likert scale. Health-related quality of life was evaluated using Patient-Reported Outcomes Measurement Information System (PROMIS) 29-item profile. PROMIS t-scores were compared between remnant radioiodine ablation and nonremnant radioiodine ablation groups, and among those with or without surgical complications.

One hundred and twenty-two pairs were matched.

--There was no significant difference in incidence of self-reported hypocalcemia, infection, dysphonia, or dysphagia between remnant radioiodine ablation and no remnant radioiodine ablation groups.

--There was no significant difference in mean PROMIS t-scores.

--Of respondents reporting normal preoperative voice and swallowing, there were no significant differences in postprocedural outcomes or PROMIS scores.

--Regardless of remnant radioiodine ablation treatment, those with surgical complications of hypocalcemia, dysphonia, or dysphagia reported worse PROMIS scores across multiple domains.

--Remnant radioiodine ablation-associated xerostomia was associated with worse PROMIS scores across multiple domains.

In particular, surgical and remnant radioiodine ablation-associated complications were associated with significantly worse PROMIS scores across multiple domains.

Surgery
Source: https://doi.org/10.1016/j.surg.2021.01.022
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