Association of Adenovirus Infection with Central Nervous Sys
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Adenovirus (Adv) is a frequent etiology of acute respiratory tract infections. Researchers retrospectively analyzed clinical, laboratory, outcome and the relationship between clinical characteristics and viral detection results in the cerebrospinal fluid (CSF) in children with Adv-associated central nervous system dysfunction.

Results:
--21 cases had Adv-associated CNS manifestations. The median age was 1.4 years and 20 were less than 5 years of age. 6 were male.

--The most frequently cited CNS symptoms were altered consciousness (100%) and seizure (14.3%).

--14 cases had abnormal electroencephalogram examination and 6 cases had abnormal imaging. None of the patients had received cidofovir administration.

--20 children recovered without sequelae and 1 patient died of respiratory failure.

--Patients with positive Adv polymerase chain reaction (n = 11) presented lower onset age compared with that of patients with negative Adv polymerase chain reaction (n = 10) in the CSF.

--Clinical manifestation, laboratory findings, imaging studies and electroencephalogram showed no significant difference between the 2 groups.

In conclusion, Adv is an unusual cause of childhood CNS disease, predominantly causing altered consciousness. Adv was found in the respiratory tract in more cases than CSF, but the virus was detected in both in the majority of patients. The absence of Adv in the CSF does not preclude CNS participation.

Source: https://journals.lww.com/pidj/Abstract/2021/03000/Adenovirus_Infection_associated_Central_Nervous.6.aspx
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