Association of Olfactory Training with Neural Connectivity i
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Viral upper respiratory tract infections are a major cause of olfactory loss. The findings of this study suggest a bimodal interaction between the visual and olfactory cortex during olfactory training (OT)and that further understanding of the association between these 2 senses for adults with postviral olfactory dysfunction (PVOD) may be useful to enhance existing OT programs.

This JAMA study was purposed to evaluate functional brain connectivity in adults with postviral olfactory dysfunction (PVOD) before and after OT using resting-state functional magnetic resonance imaging.

This prospective cohort study recruited adults with clinically diagnosed or self-reported PVOD of 3 months or longer. Baseline olfaction was measured using the University of Pennsylvania Smell Identification Test (UPSIT) and the Sniffin’ Sticks test.

A total of 16 participants with PVOD and 20 control participants completed the study.

--At baseline, participants had increased connectivity within the visual cortex when compared with normosmic control participants, a connection that subsequently decreased after OT.

--Furthermore, 4 other network connectivity values were observed to change after OT, including an increase in connectivity between the left parietal occipital junction, a region of interest associated with olfactory processing, and the cerebellum.

Overall, the use of OT is associated with connectivity changes within the visual cortex.

Source: https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2777616
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