Association of Preeclampsia with Incident Stroke in Later Li
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Contemporary research suggests an association between preeclampsia and later-life stroke among women. The JAMA findings suggest that preeclampsia may be an independent risk factor for later-life stroke among women after controlling for vascular risk factors across the life course.

The objective of this study was to assess the relative risk of incident stroke in later life among women with and without a history of preeclampsia after accounting for time-varying covariates.

This population-based cohort study was a secondary analysis of data from the Framingham Heart Study. Women were included in the analysis if they were stroke-free at enrollment and had a minimum of 3 study visits and 1 pregnancy before menopause, hysterectomy, or age 45 years. Data on vascular risk factors, history of preeclampsia, and stroke incidence were collected biannually. Participants were followed up until incident stroke or censorship from the study.

A total of 1435 women with 41?422 person-years of follow-up were included in the analytic sample. Result was:

--Of those, 169 women had a history of preeclampsia, and 231 women experienced strokes during follow-up.

--At baseline, women with preeclampsia were more likely to be younger, to be receiving cholesterol-lowering medications, to have lower cholesterol and higher diastolic blood pressure, and to currently smoke.

--The association between preeclampsia and stroke in the marginal structural model was only evident when adjustment was made for all vascular risk factors over the life course, which indicated that women with a history of preeclampsia had a higher risk of stroke in later life compared with women without a history of preeclampsia.

The findings of this cohort study suggest that preeclampsia may be a risk factor for later-life stroke among women after adjustment for time-varying vascular and demographic factors.

Source: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2778939
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