Association of Proton-pump inhibitors with increased risk of
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Since proton-pump inhibitors can be stopped or transferred to a less harmful alternative perioperatively, researchers looked into a potential connection between their use and prosthetic joint infection (PJI) in patients who had complete hip arthroplasty (THA).

Proton-pump inhibitors (PPI) have previously been associated with an increased risk of infections such as community-acquired pneumonia, gastrointestinal infections and central nervous system infection.

A case-cohort design was based on a cohort of 5,512 primary THAs; cases were described as patients with early-onset PJI. For the study design and to account for possible confounders, a weighted Cox proportional hazard regression model was used.

Results:
--There were 75 patients diagnosed with PJI of whom 32 used PPIs perioperatively compared with 75 PPI users in the control group of 302 patients.

--The risk of PJI was 2.4 times higher for patients using PPI. This effect remained after correction for possible confounders.

PPI use, in particular, was linked to an increased risk of developing PJI after THA. As a result, it appears that the use of a PPI is a modifiable risk factor for PJI.

Source: https://www.tandfonline.com/doi/full/10.1080/17453674.2021.1920687?af=R
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