Association of Weight-Adjusted Caffeine and Beta-Blocker Use
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Vitreoretinal surgery can be technically challenging and is limited by the physiologic characteristics of the surgeon. Factors that improve the accuracy and precision of the vitreoretinal surgeon are invaluable to surgical performance. A study was conducted to establish weight-adjusted cutoffs for caffeine and beta-blocker (propranolol) intake and to determine their interactions in association with the performance of novice vitreoretinal microsurgeons.

Of 15 vitreoretinal surgeons, 9 (60%) were male, with a mean age of 29.6 years and a mean body mass index of 23.15. Compared with low-dose propranolol, low-dose caffeine was associated with a worse total surgical score, a lower anti tremor maneuver score, longer intraocular trajectory, and increased task completion time. Postcaffeine treatment with propranolol was associated with performance improvement; however, surgical performance remained inferior compared with low-dose propranolol alone for total surgical score, tremor-specific score, and intraocular trajectory.

The findings suggest that the performance of novice vitreoretinal surgeons was worse after receiving low-dose caffeine alone but improved after receiving low-dose propranolol alone. Their performance after receiving propranolol alone was better than after the combination of propranolol and caffeine. These results may be helpful for novice vitreoretinal surgeons to improve microsurgical performance.

Source:https://jamanetwork.com/journals/jamaophthalmology/article-abstract/2766387

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