Association of human leukocyte antigen-G levels and gestatio
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
This study by the Journal of Obstetrics and Gynaecology Research states that decreased serum human leukocyte antigen-G levels are associated with gestational diabetes mellitus

This study was designed to determine serum human leukocyte antigen-G (HLA-G) levels and establish whether serum HLA-G level is related to gestational diabetes mellitus (GDM).

25 GDM patients aged between 24 and 34 years and 24 healthy pregnant women aged between 22 and 33 years were included in this study. The health status of subjects was determined by medical history, physical, and obstetric examinations. The absence of family history for Type 2 diabetes mellitus, absence of diagnosis or clinical evidence of any major disease, and absence of medication use altering glucose metabolism constituted the inclusion criteria. GDM cases who are at their 24–28 weeks of pregnancy and who have not been using any oral hypoglycemic agents were included in the GDM group. The Control group consisted of healthy pregnant women at their 24–28 weeks of pregnancy.

--Women with GDM had significantly lower levels of serum HLA-G than controls.

--HLA-G levels were negatively correlated with all parameters of glucose metabolism including insulin, fasting blood glucose, 1 h oral glucose tolerance test (OGTT) blood glucose, 2 h OGTT blood glucose, homeostasis model assessment, HbA1C, and WBC.

--There was a negative correlation between HLA-G and BMI.

Conclusively, decreased circulating HLA-G level is found to be associated with insulin resistance and GDM, in this study.

Source: https://doi.org/10.1111/jog.14811
1 share
Like
Comment
Share