Association of initial viral load in SARS-CoV-2 patients wit
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The dynamics of viral load (VL) of the SARS-CoV-2 and its association with different clinical parameters remain poorly characterized. In this study published in The American journal of Pathology, researchers investigate associations between VL and parameters such as severity of symptoms, disposition (admission vs direct discharge), length of hospitalization, and admission to the intensive care unit, length of need for oxygen support and overall survival.

In a cohort of 205 patients from a tertiary care center in New York City, VL was determined using q-PCR and Log10 transformed for normalization. Univariate and multivariate regression models were used to test these associations. It was found that diagnostic viral load is significantly lower in hospitalized patients than in patients not hospitalized after adjusting for age, sex, race, BMI, and comorbidities.

Higher VL was associated with shorter duration of the symptoms in all patients and hospitalized patients only and shorter hospital stay. No significant association was noted between VL, admission to ICU, length of oxygen support, and overall survival.

These findings suggest a higher shedding risk in less symptomatic patients; an important consideration for containment strategies in SARS-CoV-2. Furthermore, researchers identify a novel association between viral load and history of cancer. Larger studies are warranted to validate these findings.

Source: https://ajp.amjpathol.org/article/S0002-9440(20)30333-3/fulltext?rss=yes
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Dr. S●●●●●m S●●●●y P●●●●●l
Dr. S●●●●●m S●●●●y P●●●●●l General Medicine
Very interesting read. Clearly, the asymptomatic carriers, once again, are the real group of people that need testing. If not all,stringent contact tracing and testing at the very least is a must.
Jul 10, 2020Like2