Association of spontaneous abortion with Premature mortality
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Researchers have found in a new study that spontaneous abortion was associated with an increased risk of premature mortality, particularly death from cardiovascular disease.

This BMJ study was aimed to investigate the association of spontaneous abortion with the risk of all-cause and cause-specific premature mortality (death before the age of 70).

The prospective cohort study enrolled 101681 ever-gravid female nurses participating in the Nurses’ Health Study II. During 24 years of follow-up, 2936 premature deaths were recorded, including 1346 deaths from cancer and 269 from cardiovascular disease.

--Crude all-cause mortality rates were comparable for women with and without a history of spontaneous abortion but were higher for women experiencing three or more spontaneous abortions and for women reporting their first spontaneous abortion before the age of 24.

--The corresponding age-adjusted hazard ratios for all-cause premature death during follow-up were 1.02, 1.39, and 1.27, respectively.

--After adjusting for confounding factors and updated dietary and lifestyle factors, the occurrence of spontaneous abortion was associated with a hazard ratio of 1.19 for premature mortality during follow-up.

--The association was stronger for recurrent spontaneous abortions, and for spontaneous abortions occurring early in a woman’s reproductive life.

--When cause-specific mortality was evaluated, the association of spontaneous abortion with premature death was strongest for deaths from cardiovascular disease.

--Spontaneous abortion was not related to premature death from cancer.

Conclusively, spontaneous abortion was linked with a higher risk of premature mortality, particularly death from cardiovascular disease.

Source: https://doi.org/10.1136/bmj.n530
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