Association of vitamin D status with coronary artery disease
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The relationship between coronary artery disease (CAD) and low serum 25-hydroxyvitamin D (25(OH)D) levels has emerged.Postmenopausal (PM) women are at increased risk of CAD and vitamin D (VitD) deficiency.Vitamin D deficiency should be evaluated in PM women as a possible cause of CAD.

Vitamin D (VitD) is a fat-soluble prohormone required for Ca2+ metabolism, bone growth, and nonskeletal processes. Emerging evidence supports a link between VitD deficiency and cardiovascular disease including heart failure, peripheral vascular disease, dyslipidemia, diabetes, hypertension, and coronary artery disease (CAD).

The aim of this study was to investigate the relationship between CAD and VitD levels in PM women. This case–control study included 93 consecutive female patients aged 50 to 79 years old undergoing coronary angiography for evaluation of CAD and 119 age-matched controls. Serum 25(OH)D concentrations were classed as adequate (serum 25(OH)D: ≥20 ng/mL); insufficient (serum 25(OH)D: 10 to <20 ng/mL); and deficient (serum 25(OH)D: <10 ng/mL). Major cardiovascular risk factors were also explored.

CAD occurred in 67/127 (52.8%) patients with VitD deficiency; 21/66 (31.8%) patients that were VitD insufficient; and in 5/19 (26.3%) patients with adequate VitD levels. Multivariate regression analysis suggested that a deficiency of VitD increased CAD.

While VitD deficiency and CAD have been described extensively in the literature, their precise relationship remains unclear. Atherosclerosis in coronary arteries is critical to the pathogenesis of CAD. Inflammation plays a key role in atherosclerosis and VitD deficiency is a known cause of inflammation. Low VitD levels directly increase C-reactive protein (CRP) synthesis and the protective effects of VitD to CRP are evidenced by the distribution of VitD receptors in the vascular walls. In vivo studies have shown that a loss of VitD receptor expression influences cardiac function. VitD deficiency negatively affects the cardiovascular system through activation of the renin–angiotensin–aldosterone system. Further studies should now investigate the common pathophysiological links between VitD deficiency and CAD.

Source: https://journals.lww.com/md-journal/fulltext/2020/03130/association_of_vitamin_d_status_with_coronary.85.aspx
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Dr. M●●●●●●●j K●●●●●●●e General Medicine
My vitamin D blood level is 112. Please suggest treatment
Mar 20, 2020Like