Associations between insulin resistance and adverse pregnanc
The research reveals that insulin resistance in women with gestational diabetes mellitus is associated with adverse pregnancy outcomes.

This study aimed to explore the relationship between insulin resistance (IR) and adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM) and determine the risk factors for IR in women with GDM.

This study employed a retrospective survey of 710 women diagnosed with GDM. Serum lipids, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), and serum protein were measured in the first trimester (6–12 weeks), and OGTT and fasting insulin tests were performed in the second trimester (24–28 weeks). These results were then used to evaluate IR by homeostasis model assessment (HOMA).

- IR significantly increased the risk of the hypertensive disorders of pregnancy and large for gestational age (LGA) in women with GDM, but not for cesarean section, premature delivery, premature rupture of membranes, postpartum hemorrhage, macrosomia, and SGA.

- Compared to normal groups, greater body mass index (BMI) before pregnancy category was associated with a higher risk of IR in the second trimester, the OR were 4.09 and 6.52.

- A higher level of FPG, TG, and weight gain before the diagnosis of GDM was also associated with a higher risk of IR in the second trimester in women with GDM, while age was the weak protective factor for IR.

GDM with IR in the second trimester increased adverse pregnancy outcomes, especially the risk of hypertensive disorders of pregnancy and LGA. In addition, FPG, HbA1c, and TG in early pregnancy, pre-pregnant BMI, and weight gain before the diagnosis of GDM were all independent risk factors for IR.

BMC Pregnancy and Childbirth
Source: https://doi.org/10.1186/s12884-021-04006-x
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