Associations of atrial fibrillation with renal function decl
Chronic kidney disease (CKD) is known to increase the risk of atrial fibrillation (AF) development, but the relationship between AF and subsequent renal function decline in patients with CKD is not well understood. This study explored the role of AF on renal outcomes among patients with CKD.

In a retrospective hospital-based cohort study, we identified patients with CKD aged more than 20 years. The patients were divided into AF and non-AF groups. We matched each patient with CKD and AF to two non-AF CKD controls according to propensity scores. The outcomes of interest included estimated glomerular filtration rate (eGFR) decline of more than 20%, 30%, 40% and 50%, and end-stage renal disease (ESRD).

-- After propensity score matching, 6731 patients with AF and 13?462 matched controls were included in the analyses.

-- Compared with the non-AF group, the AF group exhibited greater risks of eGFR decline more than 20%, more than 30%, more than 40% and more than 50%, and ESRD.

-- Higher CHA2DS2-VASc scores were associated with greater risks of eGFR decline and ESRD.

Conclusively, in patients with CKD, AF was associated with greater risks of subsequent renal function decline. CHA2DS2-VASc scores may be a useful risk stratification scheme for predicting the risk of renal function decline.