Asthma linked to recurrent pregnancy loss
Asthma — especially early-onset and uncontrolled asthma — appeared significantly associated with recurrent pregnancy loss. The researchers used national health registers to examine the records of 1.3 million women in Denmark. Of them, 128,553 women aged 6 to 45 years had filled at least two prescriptions for anti-asthma drugs within 12 months between 1977 and 2019.

Compared with the women without asthma, women with asthma had higher odds of having one pregnancy loss (adjusted OR = 1.05; 95% CI, 1.03-1.07), two pregnancy losses (aOR =1.09; 95% CI, 1.05-1.13), three or more losses (aOR = 1.18; 95% CI, 1.11-1.24) and recurrent pregnancy loss (RPL; aOR = 1.19; 95% CI, 1.12-1.27).

Women with early-onset asthma, defined as onset between ages 6 and 15 years, had an aOR of 1.47 (95% CI, 1.24-1.72) for three or more pregnancy losses. Additionally, women with uncontrolled asthma — based on their use of 400 doses of short-acting beta agonists (SABA) or more per year — had an aOR of 1.6 (95% CI, 1.16-2.16) for three or more pregnancy losses compared with women with controlled asthma.