Autoimmune thyroiditis and cortico-resistant Nephrotic Syndr
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Introduction
Autoimmune diseases are very rare conditions in infancy, especially in the first year of life[1, 2, 3, 4]. We report on a case of unusual early-onset autoimmune thyroiditis in a 6-month-old child affected by nephrotic syndrome. Before that, a case of isolated autoimmune thyroiditis has been reported previously at a so early age: the patient, a 7-month-old child, died at the age of 9 months for a sepsis and his autopsy revealed a thyroid atrophy[1].

Case report
D.S. was admitted to our hospital at 6 months of age because of the appearance, two weeks before, of bilateral periorbital oedema associated with hypoalbuminemia (albumin 0.5 g/dl), hypoprotidemia (seric proteins 3.7 g/dl), proteinuria (proteinuria/creatinuria ratio 114,3) and dyslipidemia (total cholesterolemia 287 mg/dl, LDL-cholesterol 165 mg/dl, triglycerides 997 mg/dl). The diagnosis of nephrotic syndrome was established and a substitutive therapy including human albumin was immediately started, as well as calcium and potassium supplementation, diuretics and intravenous immunoglobulines. After a few days albumin levels further decreased, general conditions became more serious and subcutaneous succulence spread especially in abdominal, scrotal and palpebral regions. For this reason, it became necessary to intensify albumin infusion as well as diuretic supply and to introduce prednisone (starting dose 1 mg/Kg/die, than 0,5 mg/Kg/die) in association with an ACE-inhibitor (dose 0,5 mg/Kg/die) for its antiproteinuric effect, in order to potentiate steroid action....

https://ijponline.biomedcentral.com/articles/10.1186/1824-7288-38-57
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