Avoiding cows milk formula early on might also avoid asthma-
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Children with food allergies may develop asthma or recurrent wheeze. This study aimed to evaluate whether asthma or recurrent wheeze among children were changed by avoiding supplementing breastfeeding (BF) with cow’s milk formula (CMF) in the first 3 days of life.

In this randomized, unmasked, clinical trial, a total of 312 newborns at risk for atopy were randomized and assigned to either BF with or without amino acid–based elemental formula (EF) or BF with CMF, with follow-up examinations for participants showing signs of atopy conducted at 24 months.

Immediately after birth, newborns were randomly assigned (1:1 ratio) to either breastfeeding with or without amino acid–based elemental formula for at least the first 3 days of life (no CMF group) or breastfeeding supplemented with CMF (?5 mL/d) from the first day of life to 5 months of age (CMF group). Asthma or recurrent wheeze diagnosed by the pediatric allergy specialists of this trial; subgroups were stratified by serum levels of 25-hydroxyvitamin D and IgE.

Results:
-- Of 312 infants (156 randomized to the no CMF group), 302 were followed up at their second birthday: 77 of 151 in the no CMF group and 81 of 151 in the CMF group underwent extended follow-up because of having atopic conditions.
-- Asthma or recurrent wheeze developed in 15 of the children in the no CMF group, significantly less than the children in the CMF group.
-- In participants with vitamin D levels above the median at 5 months of age, asthma or recurrent wheeze developed in 5 children in the no CMF group, significantly less than in the children in the CMF group.
-- In the highest quartile group of total IgE at age 24 months, asthma or recurrent wheeze developed in 2 children in the no CMF group, significantly less than the children in the CMF group.

Conclusively, the findings of this study suggest that avoiding CMF supplementation in the first 3 days of life has the potential to reduce the risk of asthma or recurrent wheeze in young children, especially among those with high vitamin D or high IgE levels.

Source: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2771187
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