B-scan ultrasonography of vitreous dynamics during intravitr
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A Study was conducted to study the distribution of angiogenesis inhibitors (anti-VEGF) injected into the vitreous cavity by means of simultaneous ultrasonography.

Simultaneously with the intravitreal anti-VEGF administration, 332 B-scan ultrasound sequences of 121 eyes from 95 patients were registered. The dynamics of the injected material, as well as the presence of reflux, were examined, with the presence/absence of complete posterior vitreous detachment being associated (t-PVD).

Results:
Three well-defined patterns were distinguished.
--Pattern A: the medication penetrates the vitreous in a linear manner until reaching the retina (3.6%).

--Pattern B: the medication adopts a globular shape and then moves down reaching the retrohyaloid space (37%).

--Pattern C: the medication remains in a globular form (54%, n=180).

The pattern was not identified in 17 injections. Pattern A was only observed in vitrectomized eyes. The reflux (7.8%) was exclusive in eyes showing a C pattern. A relationship was observed between presence/absence of t-PVD, the patterns and the presence of reflux.

Finally, this research demonstrated for the first time how antiangiogenic medicine injected into the vitreous cavity behaves and how its delivery and presence of reflux is influenced by the vitreous body's previous state.

Source: https://journals.lww.com/retinajournal/Abstract/9000/B_scan_ultrasonography_of_vitreous_dynamics_during.95527.aspx
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