Basal cell carcinoma with xeroderma pigmentosum in an 8-Year
An 8-year-old girl, known case of xeroderma pigmentosum (XP), a presented with poikiloderma consisting of skin atrophy, telangiectasias, and mottled hyperpigmentation and hypopigmentation on the face, neck, and forearm that is to say on sun-exposed areas. She developed ulcerated lesions on both sides of the nose measuring 1 cm × 1 cm and 1 cm × 0.5 cm which appeared 2 months back.

She had a history of diffuse erythema, scaling, and freckle-like areas of increased pigmentation on exposure to the sun when she was 3 years old which would tend to diminish during the winter months with decreased sun exposure. These features became permanent with the passage of time. She also complained of photophobia, but there were no apparent ocular complications.

On physical examination, the child was conscious, cooperative, average built. Neurological examination was normal. Other investigations were within normal limits. She did not have a family history of the disorder. Her siblings were well and showed no signs of any illness. There was clinical suspicion of secondary malignancy. She was operated upon for the ulcerated lesions on the nose, and a biopsy was sent to the pathology.

Source: http://www.jiaps.com/temp/JIndianAssocPediatrSurg244314-2034024_053900.pdf
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