Beclin1 in Psoriasis: An Immunohistochemical Study
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Abnormal autophagy is now established to be associated with pathogenesis of some skin disorders. Beclin1 plays a central role in the machinery of the autophagy. A Study was conducted to assess the expression of "Beclin1" in psoriasis through its immunohistochemical study in lesional and perilesional skin in psoriasis cases.

This case?control study was carried out on a total number of 40 subjects, 20 patients with chronic plaque psoriasis and 20 age and sex matched apparently healthy subjects as a control group. Skin biopsies were taken from lesional, perilesional skin of psoriasis patients and normal skin from healthy controls for immunohistochemical evaluation of Beclin1 expression.

Results:
Epidermal Beclin1 expression was positive in the three studied groups. There was a significant difference between the 3 studied groups regarding epidermal topographic distribution of Beclin1, epidermal intensity of staining, Beclin1 H score and H score category. Significant differences were found between the 3 studied groups regarding skin adnexal Beclin1 H score and H score category. Regarding inflammatory infiltrate Beclin1 expression, significant differences were found between lesional and perilesional skin regarding expression status and H score and significant differences regarding intensity of staining, and H score category.

Increased Beclin1 expression in psoriasis, lesional and perilesional, indicating increased autophagy that may be a result of rapid proliferation of keratinocytes, which would also increase all cellular processes, including autophagy. Cellular localization of Beclin1 was nucleocytoplasmic in psoriasis, while cytoplasmic only in normal skin controls required interpretation in a further analysis.

Source: https://onlinelibrary.wiley.com/doi/abs/10.1111/ced.14554?af=R
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