Benign fibrous histiocytoma of the oral and maxillofacial re
The aim of the present study was to carry out a systematic review of available data regarding case reports and case series of oral and maxillofacial benign fibrous histiocytoma (BFH).

A search strategy was performed using PubMed, Web of Science, Scopus, and EMBASE electronic databases.

- Males were more affected, with a mean age of 34.55±20 years.

- The buccal mucosa represented the most common site, with the clinical presentation of a painless nodule.

- The clinical hypothesis of a fibroma was reported in the majority of the cases. Radiographic presentation of intraosseous lesions showed multilocular radiolucent images.

- Regarding the histopathologic features, the biphasic population of fibroblastic and histiocytic cells was seen in 21 cases and a spindle-shaped fibroblastic cell population organized into a storiform pattern was observed in 25 cases.

- CD68 and vimentin showed immunoreactivity in all BFH cases in which they were used. All cases were treated with surgical resection and 8.10% recurred.

The current systematic review demonstrated that BFH represents a rare lesion that mainly affects the buccal mucosa of males, and that the treatment is mainly surgical, with a good prognosis.

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology