Bilateral oophorectomy increases risk for severe carpal tunn
Premenopausal women who underwent bilateral oophorectomy had a higher risk for severe carpal tunnel syndrome compared with women who did not have the procedure, according to a study published in Menopause.

The incidence of carpal tunnel syndrome (CTS) is higher in women, and peaks around the age of menopause. Therefore, we investigated whether bilateral oophorectomy is associated with an increased risk of severe CTS.

Researchers included all of the 1,653 premenopausal women who underwent bilateral oophorectomy for a nonmalignant indication between 1988 and 2007, and a random sample of 1,653 age-matched referent women who did not undergo bilateral oophorectomy in Olmsted County, MN. Diagnoses of CTS assigned to women over their entire lifetime were identified in these two cohorts. The risk of de novo severe CTS after bilateral oophorectomy (or index date) was evaluated using Cox proportional hazards models adjusted for potential confounders.

-- Bilateral oophorectomy was associated with an increased risk of severe CTS.

-- The risk was suggestively greater in women with lower body mass index, nulliparity, and with a benign ovarian indication for oophorectomy (nonsignificant interactions).

-- No protective effect of estrogen therapy after the oophorectomy was observed.

-- The findings were similar in secondary analyses considering the incidence of CTS of any severity or idiopathic CTS.

The risk of severe CTS, common in perimenopausal women, is increased after bilateral oophorectomy. The association may be causal or due to confounding. Therefore, the precise biological mechanisms explaining the association and the absence of a mitigating effect of estrogen therapy should be further investigated.

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