Bladder Instillations With Triamcinolone Acetonide for Inter
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
The study results show that bladder instillations with triamcinolone acetonide are not effective for interstitial cystitis–bladder pain syndrome.

The study by Obstetrics & Gynecology was aimed to evaluate the utility of adding triamcinolone acetonide to a standard bladder instillation solution for the treatment of interstitial cystitis–bladder pain syndrome.

This was a single-center, randomized, double-blind trial that compared symptom response in women with interstitial cystitis–bladder pain syndrome who underwent six bladder instillations with triamcinolone acetonide or six instillations without. All instillation solutions contained heparin, viscous lidocaine, sodium bicarbonate, and bupivacaine. The primary outcome was the change in symptoms from the first to sixth bladder instillation between groups based on the total OLS score. Assuming a 4.03-point or larger difference in the mean total OLS score from the first to sixth bladder instillation as compared between the groups, 64 participants were needed to show a significant difference with 80% power at the 0.05 significance level.

90 women were enrolled; 71 completed all six bladder instillations. Randomization resulted in groups with similar characteristics. There was no difference between groups in the primary outcome. Women in both groups had improvement in their interstitial cystitis–bladder pain syndrome symptoms as indicated by a decrease in the total OLS score from the first to sixth bladder instillation.

Conclusively, the addition of triamcinolone acetonide to a standard bladder instillation solution does not improve symptoms associated with interstitial cystitis–bladder pain syndrome.

Source: https://journals.lww.com/greenjournal/Abstract/2021/05000/Bladder_Instillations_With_Triamcinolone_Acetonide.9.aspx
Like
Comment
Share