Blood Glucose on Admission Predicts COVID-19 Severity in All
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Hyperglycaemia has emerged as an important risk factor for death in COVID-19. The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19.

This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients were categorized into three groups according to admission BG levels: less than 140 mg/dL, 140–180 mg/dL and gretaer than 180 mg/dL. The primary endpoint was all-cause in-hospital mortality.

Results:
-- Of the 11,312 patients, only 2128 (18.9%) had diabetes and 2289 (20.4%) died during hospitalization.

-- The in-hospital mortality rates were 15.7% (less than 140 mg/dL), 33.7% (140–180 mg) and 41.1% (greater than 180 mg/dL).

-- The cumulative probability of mortality was significantly higher in patients with hyperglycaemia compared to patients with normoglycaemia, independently of pre-existing diabetes. Hyperglycaemia (after adjusting for age, diabetes, hypertension and other confounding factors) was an independent risk factor of mortality.

-- Hyperglycaemia was also associated with requirement for mechanical ventilation, intensive care unit (ICU) admission and mortality.

Conclusively, admission hyperglycaemia is a strong predictor of all-cause mortality in non-critically hospitalized COVID-19 patients regardless of prior history of diabetes.

Key Takeaways:

- Admission hyperglycaemia is a stronger and independent risk factor for mortality in COVID-19.

- Screening for hyperglycaemia, in patients without diabetes, and early treatment of hyperglycaemia should be mandatory in the management of patients hospitalized with COVID-19.

- Admission hyperglycaemia should not be overlooked in all patients regardless prior history of diabetes.

Source: https://www.tandfonline.com/doi/abs/10.1080/07853890.2020.1836566
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