Blood Vessel Damage And Inflammation In COVID-19 Patients’ B
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A study found that the brains of patients who contract infection from SARS-CoV-2 may be susceptible to microvascular blood vessel damage. Our results suggest that this may be caused by the body’s inflammatory response to the virus.

The researchers conducted an in-depth examination of brain tissue samples from 19 patients who had died of COVID-19. The patients died at a wide range of ages, from 5 to 73 years old. They died within a few hours to two months after reporting symptoms. Many patients had one or more risk factors, including diabetes, obesity, and cardiovascular disease.

The researchers used a special, high-powered magnetic resonance imaging (MRI) scanner to examine samples of the olfactory bulbs and brainstem. The scans revealed that both regions had hyperintensities, that often indicate inflammation, hypointensities, that represent bleeding.

The researchers examined the spots more closely under a microscope. The spots were surrounded by T cells from the blood and the brain’s own immune cells called microglia. In contrast, the dark spots contained both clotted and leaky blood vessels but no immune response. This appeared to trigger an immune reaction.

Finally, the researchers saw no signs of infection in the brain tissue samples even though they used several methods for detecting genetic material or proteins from SARS-CoV-2.

Source:
https://www.nih.gov/news-events/news-releases/nih-study-uncovers-blood-vessel-damage-inflammation-covid-19-patients-brains-no-infection
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