Blood and Salivary MicroRNAs for Diagnosis of Oral Squamous
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This meta-analysis aimed to compare and evaluate the diagnostic accuracy of blood and salivary microRNAs (miRNAs) in discriminating oral squamous cell carcinoma (OSCC). The PubMed, EMBASE, Web of Science and Cochrane Library were searched (updated to Feb, 2020) to identify all articles describing the diagnostic value of blood and salivary miRNAs for oral squamous cell carcinoma. The pooled parameters were calculated. 20 articles involving 1106 patients and 732 controls were included in this meta-analysis. The pooled sensitivity and specificity of salivary miRNAs were 0.70 and 0.82. For blood miRNAs, they were 0.79 and 0.82. The areas under the receiver operating characteristic curve in saliva, blood, and body fluid miRNAs were 0.80, 0.88, and 0.87,

The results of this meta-analysis indicate a moderate diagnostic accuracy of blood and salivary miRNAs presented for oral squamous cell carcinoma. These findings may provide less invasive and relatively reliable diagnostic tools for oral squamous cell carcinoma detection.

Source:https://www.joms.org/article/S0278-2391(20)31541-X/fulltext?rss=yes
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