Blood test could predict diabetes years before it strikes
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Women with a history of gestational diabetes mellitus (GDM) have a 7-fold higher risk of developing type 2 diabetes (T2D) later in life, and an estimated 35%–50% of GDM cases will progress to T2D within 10 years postpartum. Biological pathways and metabolites influencing progression from GDM to T2D have not been elucidated in humans.

The main goal of the present work was to gain critical insight into the pathology of the transition from GDM to T2D, particularly metabolic changes involved in this process. A second goal was to devise more accurate means of identifying who will transition to T2D among women with GDM.

What did the researchers do and find?

They carried out a nested case–control study using a GDM prospective cohort of 1,010 women without T2D 6–9 weeks postpartum (study baseline). Then they performed metabolic profiling on fasting blood samples from women at 6–9 weeks postpartum (baseline) and up to 2 years post-baseline (follow-up).

Researchers found that significant dysmetabolism in lipids and amino acids in the early postpartum period was associated with future diabetes in women. Longitudinal analysis tracking changes in metabolic profiles over the course of diabetes progression revealed 10 specific metabolites that are associated with progression to T2D. They identified a small group of metabolites that could predict future T2D with great discriminative power, surpassing current clinical methods.

Conclusively, a subclinical diabetes-like condition appears to already be present in the early postpartum period in women with previous GDM who later progress to T2D, and dysregulated amino acid metabolism is tightly associated with disease progression. Metabolites other than glucose may provide a simple and accurate alternative approach to assess risk of future T2D in women with a history of GDM.

Source: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003112
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Dr. S●●●●●m S●●●●y P●●●●●l
Dr. S●●●●●m S●●●●y P●●●●●l General Medicine
Necessary,as the contact of uneducated lower SE status women is very low,and this is one of the few chances to catch the "to-be" patients.
May 24, 2020Like1