Blood vessel breakthrough major step towards Alzheimer's tre
Alzheimer's Disease is traditionally thought of as a disease of the brain cells, where a protein called Amyloid-beta (A) accumulates and forms plaques. There is growing evidence that the blood supply to the brain is also affected, however, how this happens is unknown.

A smaller version of the protein—called Amyloid- 1-40 (A 1-40)—builds up in the walls of the small arteries and reduces blood flow to the brain. The surface of the brain is covered with small arteries, called pial arteries, that control the brain's supply of blood and oxygen. If these arteries become narrowed for too long, the brain can't get enough nutrients. This is one of the causes of memory loss seen in people with the disease.

Source: https://dx.doi.org/10.1073/pnas.2204581119
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