Bone mineral benefits of denosumab for postmenopausal women
Researchers collected bone matrix quality data from the FREEDOM and FREEDOM extension trials, in which postmenopausal women aged 60 to 90 years were randomly assigned to 60 mg denosumab or placebo every 6 months for 3 years. The extension trial followed up with participants at 5 and 10 years. The analysis included 42 participants from FREEDOM receiving denosumab and 30 from the placebo group. There were 28 participants from the FREEDOM extension 5-year follow-up included in the analysis and 21 from the 10-year follow-up.

In the FREEDOM trial analysis, mineral to matrix bone ratio at both the cortical and cancellous compartments was higher in the denosumab group compared with placebo. Microhardness was higher in those assigned denosumab compared with placebo in the cortical bone only.

Women in the 5-year follow-up group had a higher mineral to matrix ratio in both the cortical and cancellous bone at 5 years compared with 2 to 3 years. The mineral to matrix ratio in both compartments was unchanged at 10 years compared with 5 years. Mineral maturity and crystallinity were also higher at 5 years compared with 2 to 3 years, with no mineral maturity and crystallinity changes observed at 10 years, except for mineral maturity in the cancellous bone, which was higher at 10 years compared with 5 years. Postmenopausal women assigned denosumab have increases in mineral to matrix ratio at the cortical and cancellous bone at 2 to 3 years, but changes were not observed beyond 5 years.

Source: https://www.healio.com/news/endocrinology/20220504/bone-mineral-benefits-of-denosumab-for-postmenopausal-women-observed-for-up-to-5-years
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