Bowel perforation in a newborn exposed to cocaine in utero
The present case has been reported in the journal Pediatrics and Neonatology.

A full-term male neonate without perinatal problems presented with irritability, tremors, and episodes of clonus of the limbs in the first days of life. He was treated with phenobarbital. The mother was a cocaine abuser; the toxicological screen test of the newborn's urine was positive for cocaine and opiates.

On the 10th day of life, the infant started presenting stools with abundant red blood and an increase in CRP levels and developed a sudden clinical deterioration with tense abdomen and sore. An abdominal X-ray showed free air in the abdominal cavity, suggesting a bowel perforation.

The infant underwent laparotomic surgery, during which the surgeons found an isolated perforation of the transverse colon. A segmental resection of the colon tract was performed by creating a termino-terminal anastomosis. Histological examination revealed multiple foci of transmural necrosis with perforation and serositis. The postoperative course was uneventful.

Read more here: