Brain metastasis in advanced serous borderline tumor of the
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Ovarian neoplasms are defined on a spectrum that includes borderline, low-grade, and high-grade tumors. A two-tier classification system is used to grade serous neoplasms as low grade or high grade—two tumor types with distinct molecular, pathologic, and clinical features. Serous borderline tumors represent a premalignant lesion with the ability to progress to low-grade serous carcinoma (LGSC). According to the National Comprehensive Cancer Network, the standard treatment for surgically staged borderline epithelial tumors with non-invasive implants is observation. For those with invasive implants, the standard of care also is observation or consideration of systemic treatment, as is recommended for the treatment of LGSC. This article reports on a patient who had been diagnosed with recurrent serous borderline tumor with micropapillary architecture, invasive and non-invasive implants, and metastasis to the brain...

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